PRGL493 是一种有效的选择性长链酰基辅酶A 合成酶 4 (ACSL4) 抑制剂。 PRGL493 阻断乳腺和前列腺细胞和动物模型中的细胞增殖和肿瘤生长。 PRGL493 用于癌症研究。
| Cas No. | 2479378-45-3 |
| Canonical SMILES | CC(NC1=NC2=NC3=C(C=CC=C3)N2C(C4=CN(C5=CC=CC=C5)N=C4C6=CC=C(C)O6)N1)=O |
| 分子式 | C25H21N7O2 |
| 分子量 | 451.5 |
| 溶解度 | Chloroform: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 µM. PRGL493 (5 µM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg. 1.Castillo, A.F., Orlando, U.D., Maloberti, P.M., et al.New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesisCell. Mol. Life Sci.(2020) |
