Neuropeptide S(human)(acetate)

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Neuropeptide S(human)(acetate)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
500 μg	询价
1mg	询价

A neuropeptide NSPR agonist

Canonical SMILES	[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](C(C)C)C(NCC(N[C@]([C@@H](C)O)([H])C(NCC(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CO)C(O)=O)=O)=O)C)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O.CC(O)=O
分子式	C₉₃H₁₅₅N₃₁O₂₈S.XC₂H₄O₂
分子量	2187.5
溶解度	Water: 1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Neuropeptide S is a neuropeptide expressed in the brain, primarily in glutamatergic neurons near the locus coeruleus and in the trigeminal sensory nucleus, as well as in neurons of the lateral parabrachial nucleus in rat brain.¹It is an agonist of the neuropeptide S receptor (NPSR) with an EC₅₀value of 9.4 nM for the human peptide to induce intracellular calcium mobilization in HEK293 cells expressing the human receptor.²Neuropeptide S (0.1-1 nmol), administered either intracerebroventricularly or into the paraventricular nucleus (PVN) of the hypothalamus, increases plasma adrenocorticotropic hormone (ACTH) and corticosterone levels in rats.³Administration into the PVN also decreases food intake in the hour following doses of 0.1, 0.3, and 1 nmol. Neuropeptide S decreases anxiety-like and fear behaviors in rodents, decreasing defensive burying in rats, increasing the time mice spend in the open arms of the elevated plus maze, and enhancing contextual fear extinction in mice.^4,5 1.Xu, Y.-L., Gall, C.M., Jackson, V.R., et al.Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brainJ. Comp. Neurol.500(1)84-102(2007) 2.Xu, Y.-L., Reinscheid, R.K., Huitron-Resendiz, S., et al.Neuropeptide S: A neuropeptide promoting arousal and anxiolytic-like effectsNeuron43(4)487-497(2004) 3.Smith, K.L., Patterson, M.L., Dhillo, W.S., et al.Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intakeEndocrinology147(7)3510-3518(2006) 4.Vitale, G., Filaferro, M., Ruggieri, V., et al.Anxiolytic-like effect of neuropeptide S in the rat defensive buryingPeptides29(12)2286-2291(2008) 5.JÜngling, K., Seidenbecher, T., Sosulina, L., et al.Neuropeptide S-mediated control of fear expression and extinction: Role of intercalated GABAergic neurons in the amygdalaNeuron59(2)298-310(2008)

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