SAG dihydrochloride 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。 SAG dihydrochloride 激活 Hedgehog 信号通路并抵消 Cyclopamine 对 Smo 的抑制作用。
| Canonical SMILES | ClC1=C(C(N([C@H]2CC[C@H](NC)CC2)CC3=CC=CC(C4=CC=NC=C4)=C3)=O)SC5=CC=CC=C51 |
| 分子式 | C28H28ClN3OS.2HCl |
| 分子量 | 562.98 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dihydrochloride salt of SAG; a potent Smoothened (Smo) receptor agonist. 0 |
