A potential impurity in commercial preparations of gabapentin
| Cas No. | 67950-95-2 |
| 别名 | 加巴喷丁杂质E |
| Canonical SMILES | O=C(CC1(CCCCC1)C(O)=O)O |
| 分子式 | C9H14O4 |
| 分子量 | 186.2 |
| 溶解度 | DMF: 20 mg/mL,DMSO: 33 mg/mL,Ethanol: 25 mg/mL,PBS (pH 7.2): 0.16 mg/mL |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 1-Carboxycyclohexaneacetic acid is a potential impurity in commercial preparations of the antiepileptic gabapentin.1It has also been used as a precursor in the synthesis of antagonists of the serotonin (5-HT) receptor subtype 5-HT2A.2 1.Ragham, P.K., and Chandrasekhar, K.B.Development and validation of a stability-indicating RP-HPL C-CAD method for gabapentin and its related impurities in presence of degradation productsJ. Pharm. Biomed. Anal.125122-129(2016)
2.Obniska, J., Pawlowski, M., Kolaczkowski, M., et al.Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dionePol. J. Pharmacol.55(4)553-557(2003) |
