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Cyclizine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cyclizine图片
CAS NO:82-92-8
包装与价格：
包装价格(元)
10mg询价
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100mg询价

Cyclizine，一种哌嗪衍生物，是一种有效的选择性组胺 H1 受体拮抗剂。Cyclizine 可用于恶心、呕吐和头晕的研究。
Cas No.82-92-8
别名苯甲嗪
分子式C18H22N2
分子量266.38
溶解度DMSO : 100 mg/mL (375.40 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness[1][2][3].

Cyclizine (100 μM) significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants[1].Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 µM[2].

Cyclizine (1, 10 mg/kg) enhances locomotor activity of mice in a dose-dependent manner[3].

[1]. KrÁlovÁ J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9(7-8):990-5.
[2]. Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69(4):663-7.
[3]. Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22(2):293-6.

 
 
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