An internal standard for the quantification of (±)-ibuprofen
| Cas No. | 1219805-09-0 |
| 别名 | 布洛芬钠-D3,(±)-Ibuprofen-d3 sodium |
| Canonical SMILES | [O-]C(C(C1=CC=C(C=C1)CC(C)C)C([2H])([2H])[2H])=O.[Na+] |
| 分子式 | C13H14D3O2• Na |
| 分子量 | 231.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 2 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (±)-Ibuprofen-d3is intended for use as an internal standard for the quantification of (±)-ibuprofen by GC- or LC-MS. (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC50s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively).1In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED50= 6.1 mg/kg).2It also inhibits acetic acid-induced writhing in mice (ED50= 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain. 1.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995)
2.Seguin, L., Le Marouille-Girardon, S., and Millan, M.J.Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: A comparison to other classes of antinociceptive agentPain61(2)325-343(1995) |
