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IRL 1620(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IRL 1620(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
500 µg询价
1mg询价
5mg询价

A peptide ETBreceptor agonist
Canonical SMILESOC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C=C2)=CC=C2O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O.OC(C(F)(F)F)=O
分子式C86H117N17O27• XCF3COOH
分子量1820.9
溶解度Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IRL 1620 is a peptide endothelin type B (ETB) receptor agonist.1It selectively binds to ETBreceptors (Ki= 16 pM) over ETAreceptors (IC50= 1.9 µM) and induces contraction of isolated guinea pig trachea when used at concentrations ranging from 0.01 to 1 µM. IRL 1620 (1 nmol/kg) reduces mean arterial pressure (MAP) in normotensive rats and spontaneously hypertensive rats (SHRs) and diminishes the transient depressor response in SHRs.2It reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia.3IRL 1620 also improves spatial memory deficits induced by amyloid-β (Aβ) in a rat model of Alzheimer’s disease.

1.Takai, M., Umemura, I., Yamasaki, K., et al.A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptorBiochem. Biophys. Res. Commun.184(2)953-959(1992) 2.James, A.F., Urade, Y., Webb, R.L., et al.IRL 1620, succinyl-[Glu9,Ala11,15]-endothelin-1(8-21), a highly specific agonist of the ETB receptorCardiovasc. Drug Rev.11(3)253-270(1993) 3.Gulati, A., Hornick, M.G., Briyal, S., et al.A novel neuroregenerative approach using ETB receptor agonist, IRL-1620, to treat CNS disordersPhysiol. Res.67(Suppl 1)S95-S113(2018)

 
 
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