| 产品描述 | Norfluoxetine-d5is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine.1It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A.2Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki= 44.7 nM) and isolated human platelets (IC50= ~15 nM).1It has been found in the tissues of fish exposed to wastewater effluent.3 1.Wong, D.T., Bymaster, F.P., Reid, L.R., et al.Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brainNeuropsychopharmacology8(4)337-344(1993)
2.Hiemke, C., and HÄrtter, S.Pharmacokinetics of selective serotonin reuptake inhibitorsPharmacol. Ther.85(1)11-28(2000)
3.Brooks, B.W., Chambliss, C.K., Stanley, J.K., et al.Determination of select antidepressants in fish from an effluent-dominated streamEnviron. Toxicol. Chem.24(2)464-469(2005) |
