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(E/Z)-Sivopixant
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(E/Z)-Sivopixant图片
CAS NO:1640808-39-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
5mg询价
10mg询价
25mg询价
50mg询价
100mg询价

(E/Z)-Sivopixant (Compound I-127) 是一种有效的 P2X3 受体拮抗剂，IC50 为 4 nM。(E/Z)-Sivopixant 可用于呼吸系统疾病研究。
Cas No.1640808-39-4
别名(E/Z)-S-600918
分子式C25H22ClN5O5
分子量507.93
溶解度DMSO : 100 mg/mL (196.88 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(E/Z)-Sivopixant (Compound I-127) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research[1].

ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors It has been suggested that it is involved in information transmission in the respiratory organs[1].

[1]. Kai, Hiroyuki, et al. Amino-triazine derivatives and pharmaceutical composition containing said derivatives. WO2014200078A1.

 
 
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