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Ac-Endothelin-1(16-21),human
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ac-Endothelin-1(16-21),human图片
包装与价格：
包装价格(元)
1mg询价
5mg询价
10mg询价
25mg询价

ETA/ETB agonist,vasoconstrictor

别名Ac-His-Leu-Asp-Ile-Ile-Trp-OH
Canonical SMILESO=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](C)CC)C(N[C@@H]([C@H](C)CC)C(N[C@@H](CC1=CC(C=CC=C2)=C2N1)C(O)=O)=O)=O)=O)=O)[C@H](CC3=CNC=N3)NC(C)=O
分子式C41H59N9O10
分子量837.96
溶解度≥ 83.8mg/mL in DMSO with gentle warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues, including the heart, the kidney, and the central nervous system.
At the cellular level, the effects of ET-1 appear to be mediated by two specific receptor subtypes termed ETA and ETB, both of which are functionally coupled to phospholipase C (PLC).
The C-terminal fragment , which is a highly conserved sequence in the peptides of the ET family, has been shown to discriminate between the two ET receptor subtypes termed ETA and ETB since it activates only the latter ones.

References:
1. Rubanyi, G. M., and M. A. Polokoff. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46: 325–415, 1994
2. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375–411.
3. PM Vanhoutte Endothelin-1. A matter of life and breath, Nature, 368 (1994), pp. 693–694

 
 
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