Bis-PEG13-NHS ester

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Bis-PEG13-NHS ester

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2221949-00-2

包装与价格：

包装	价格(元)
250mg	询价
500mg	询价
1g	询价

Bis-PEG13-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。Bis-PEG13-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG13-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

Cas No.	2221949-00-2
分子式	C₃₈H₆₄N₂O₂₁
分子量	884.92
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Bis-PEG13-NHS ester is a PEG/Alkyl/ether-basedPROTAC linkercan be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)^[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. [1]. John L. Magnani, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1