L-Methionine-(S,R)-Sulfoximine (MSX) 是谷氨酰胺合成酶的抑制剂。
| Cas No. | 15985-39-4 |
| 别名 | L-蛋氨酸磺酸盐,MSX; MSO |
| Canonical SMILES | N[C@H](C(O)=O)CCS(C)(=N)=O |
| 分子式 | C5H12N2O3S |
| 分子量 | 180.2 |
| 溶解度 | PBS (pH 7.2): 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | L-Methionine-(S,R)-sulfoximine is an inhibitor of glutamine synthetase and a sulfoximine derivative of L-methionine.1 It inhibits pea glutamine synthetase by 31 to 64% when used at concentrations ranging from 5 to 25 μM following preincubation with L-glutamine, an effect that is absent without L-glutamine preincubation. It also inhibits glutamine synthetase in isolated chick embryo retinas.2 References
1. Sinden, S.L., and Durbin, R.D. Glutamine synthetase inhibition: Possible mode of action of wildfire toxin from Pseudomonas tabaci. Nature 219(5152), 379-380 (1968).
2. Reif-Lehrer, L., and Coghlin, J. Conversion of glutamic acid to glutamine by retinal glutamine synthetase. Exp. Eye. Res. 17(4), 321-328 (1973). |
