(-)-Rasfonin 是一种真菌次生代谢物，可抑制小 G 蛋白 Ras。 (-)-Rasfonin 在 ACHN 细胞（一种肾癌细胞系）中诱导细胞凋亡、坏死和自噬。
| Cas No. | 303156-68-5 |
| 别名 | 拉斯弗宁 |
| 化学名 | (2E,4E,6S)-8-hydroxy-6-(hydroxymethyl)-4-methyl-2,4-octadienoic acid, (2R,3R)-3,6-dihydro-6-oxo-2-[(1S,3R,5E)-1,3,5-trimethyl-5-hepten-1-yl]-2H-pyran-3-yl ester |
| Canonical SMILES | O=C1O[C@@]([C@@H](C)C[C@@H](C)C/C(C)=C/C)([H])[C@H](OC(/C=C/C(C)=C/[C@@H](CO)CCO)=O)C=C1 |
| 分子式 | C25H38O6 |
| 分子量 | 434.6 |
| 溶解度 | DMSO: 1 mg/ml,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (-)-Rasfonin is a fungal metabolite that has been found in T. terrophilus.1 It inhibits proliferation of mouse splenocytes induced by concanavalin A and LPS (IC50s = 0.7 and 0.5 μg/ml, respectively). References
1. Fujimoto, H., Okamoto, Y., Sone, E., et al. Eleven new 2-pyrones from a fungi imperfecti, Trichurus terrophilus, found in a screening study guided by immunomodulatory activity. Chem. Pharm. Bull. (Tokyo) 53(8), 923-929 (2005). |
