ACT-373898 是 Macitentan 的一种无活性羧酸代谢物。
| Cas No. | 1433875-14-9 |
| Canonical SMILES | O=C(COC1=C(C2=CC=C(C=C2)Br)C(NS(=O)(NCCC)=O)=NC=N1)O |
| 分子式 | C15H17BrN4O5S |
| 分子量 | 445.3 |
| 溶解度 | DMSO: soluble,Ethanol: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1 1.Dingemanse, J., Sidharta, P.N., Maddrey, W.C., et al.Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertensionExpert Opin. Drug Saf.13(3)391-405(2013) |
