Brr2-IN-3 是一种有效的选择性 Brr2 解旋酶变构抑制剂。Brr2-IN-3 抑制解旋酶活性的 IC50 值为 1.3 μM，且呈剂量依赖性。
| Cas No. | 2104030-82-0 |
| 分子式 | C24H20N4O3S |
| 分子量 | 444.51 |
| 溶解度 | DMSO : 50 mg/mL (112.48 mM; Need ultrasonic) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM[1]. [1]. Iwatani-Yoshihara M, et al. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem. 2017;60(13):5759-5771. |
