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BT18
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BT18图片
CAS NO:924811-53-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
5mg询价
10mg询价
50mg询价
100mg询价

BT18 是一种功能类似于胶质细胞源神经营养因子 (GDNF) 的分子模拟物。BT18 影响 GDNF 家族受体 GFRα1 和 RET 受体酪氨酸激酶 RetA 的功能。
Cas No.924811-53-0
分子式C30H31F4N3O6S
分子量637.64
溶解度DMSO : 100 mg/mL (156.83 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].

BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells[1].

[1]. Leo Jakman, Characterization of small-molecule GDNF mimics.
[2]. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414.

 
 
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