A leukotriene receptor antagonist
| Cas No. | 40786-08-1 |
| Canonical SMILES | O=C(C(OC1=C(CCC)C(OCC(COC2=C(CCC)C(O)=C(C(C)=O)C=C2)O)=CC=C13)=CC3=O)[O-].[Na+] |
| 分子式 | C27H29O9• Na |
| 分子量 | 520.5 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | FPL 55712 (sodium salt) is a leukotriene (LT) receptor antagonist.1It inhibits the binding of LTD4to guinea pig lung homogenates (IC50= 4 µM) and reduces LTD4-induced contraction of isolated guinea pig tracheal smooth muscle (pA2= 1 µM). FPL 55712 (sodium salt) inhibits bronchoconstriction induced by LTD4, LTC4, or LTE4in guinea pigs (ID50s = 2, 6, and 1 mg/kg, respectively). 1.Cohen, N., Weber, G., Banner, B.L., et al.3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonistsJ. Med. Chem.32(8)1842-1860(1989) |
