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Doxycycline
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Doxycycline图片
CAS NO:564-25-0
包装与价格：
包装价格(元)
25mg询价
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Doxycycline 是一种四环素抗生素，口服有效的，广谱的金属蛋白酶 (MMP) 抑制剂，具有抗菌活性。

Cas No.564-25-0
别名多西环素
分子式C22H24N2O8
分子量444.43
溶解度DMSO : 125 mg/mL (281.26 mM; Need ultrasonic)
储存条件Store at 4℃, protect from light, stored under argon
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1].

Doxycycline affects growth of glioma cells only under high concentrations[2]. Doxycycline decreases MT-CO1 protein content with concentrations of 1 &#181g/mL and higher in SVG cells[2]. Doxycycline (1 &#181g/mL) induce short-hairpin RNA (shRNA) expression in H23 cells[3].

Doxycycline (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner[1].

[1]. Briest W, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7.
[2]. Luger AL, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5).
[3]. Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30;534(7609):647-51.

 
 
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