Apcin-A，是 Apcin 衍生物，是一种后期促进复合物 (APC) 抑制剂。Apcin-A 与 Cdc20 强烈相互作用，抑制 Cdc20 底物的泛素化。Apcin-A 可用于合成 PROTAC CP5V 。
| Cas No. | 1683617-62-0 |
| 分子式 | C10H14Cl3N5O2 |
| 分子量 | 342.61 |
| 溶解度 | DMSO : 100 mg/mL (291.88 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V [1]. [1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2. |
