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Acumapimod
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Acumapimod图片
CAS NO:836683-15-9
包装与价格：
包装价格(元)
5mg询价
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Acumapimod (BCT197) 是一种具有口服活性的 p38 MAP 激酶抑制剂，对 p38α 的 IC50 小于 1 μM。
Cas No.836683-15-9
别名BCT197
Canonical SMILESO=C(NC1CC1)C2=CC=C(C)C(N3N=CC(C(C4=CC=CC(C#N)=C4)=O)=C3N)=C2
分子式C22H19N5O2
分子量385.42
溶解度DMSO : ≥ 50 mg/mL (129.73 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.

Acumapimod is an inhibitor of p38α with an IC50 value of less than 1 uM.

BCT197 is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of BCT197 (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients[2].

References:
[1]. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92.
[2]. De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.

 
 
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