Skyrin

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Skyrin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Cas No.	602-06-2
别名	穗花衫双黄酮,Endothianin，Rhodophyscin
化学名	2,2',4,4',5,5'-hexahydroxy-7,7'-dimethyl-[1S,1'-bianthracene]-9,9',10,10'-tetrone
Canonical SMILES	CC1=CC(O)=C2C(C(C(C(C3=C(O)C=C(O)C(C(C4=C5C=C(C)C=C4O)=O)=C3C5=O)=C(O)C=C6O)=C6C2=O)=O)=C1
分子式	C₃₀H₁₈O₁₀
分子量	538.5
溶解度	DMSO: soluble,Ethanol: soluble
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor. At 10 μM, skyrin reduces both glucagon-stimulated cAMP production and glycogenolysis. It does not interfere with epinephrine or glucagon-like peptide 1 effects on these parameters.[1] Reference： [1]. Parker, J.C., McPherson, R.K., Andrews, K.M., et al. Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes. Diabetes 49, 2079-2086 (2012).