TrkA-IN-1 是一种有效的选择性肌球蛋白相关激酶 A (TrkA) 抑制剂，在基于细胞的测定中，IC50 为 99 nM。TrkA-IN-1 具有镇痛作用。
| Cas No. | 1680179-43-4 |
| Canonical SMILES | O=C(NC1=CN=C(C)N=C1C2=CC=CC=C2)NC3C4=C(C5=C3C=CC=C5)C=CC=C4 |
| 分子式 | C25H20N4O |
| 分子量 | 392.45 |
| 溶解度 | DMSO: 8.33 mg/mL (21.23 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity[1]. [1]. Su HP , et al. Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E297-E306. |
