ZAP 180013 是一种 zeta 链相关蛋白激酶 70 (ZAP-70) 抑制剂，IC50 为 1.8 μM。
| Cas No. | 873080-25-2 |
| Canonical SMILES | O=C(N(CC1=CC=C(Cl)C=C1)CC2=CC=CO2)C3=NC(S(=O)(CC)=O)=NC=C3Cl |
| 分子式 | C19H17Cl2N3O4S |
| 分子量 | 454.32 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway. Visperas et al (2017) Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen. SLAS.Discov. 22 324 PMID:27932698 |
