An inhibitor of NGF-p75 NGFR interactions
| Canonical SMILES | O=C(NC1=CC=C(N(C)C2=CC(C(O)=O)=NN2C3=O)C3=C1)C4=CC=CC=C4.O |
| 分子式 | C19H14N4O4• XH2O |
| 分子量 | 362.3 |
| 溶解度 | DMSO: 36 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PD 90780 is an inhibitor of the interaction between NGF and the p75 NGF receptor (NGFR).1 It binds to NGF (KD = 25.83 μM) and inhibits NGF binding to the extracellular domain of p75 NGFR (IC50 = 220 nM), as well as to Q1-CHO cells expressing full-length human p75 NGFR (IC50 = 300 nM).1,2 PD 90780 inhibits NGF-dependent differentiation of PC12 cells (IC50 = 33.22 μM).2 |
