| CAS NO: | 2349368-16-5 |
| Cas No. | 2349368-16-5 |
| Canonical SMILES | O=S(C1=CC=C(CC(NC2=CC=C(C3=C(F)C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C3)C=C2)=O)C=C1)(CC)=O |
| 分子式 | C25H20F7NO4S |
| 分子量 | 563.48 |
| 溶解度 | DMSO: 250 mg/mL (443.67 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM[1]. IC50: 30 nM (RORγ)[1]Kd: 380 nM (RORγ)[1] XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA)[1]. XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss[1]. [1]. Zhang Y, et al. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2019 May 9;62(9):4716-4730. |
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