bio-THZ1 是THZ1 的生物素结构，与CDK7 不可逆的结合。THZ1 是有效，选择性的共价 CDK7 抑制剂，IC50 为 3.2 nM。
| Cas No. | 1604811-14-4 |
| 分子式 | C52H65ClN12O8S |
| 分子量 | 1053.67 |
| 溶解度 | DMSO : 120 mg/mL (113.89 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM[1]. [1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20. |
