| CAS NO: | 2229974-83-6 |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 10mg | 询价 |
| Cas No. | 2229974-83-6 |
| 分子式 | C39H40N10O7 |
| 分子量 | 760.8 |
| 溶解度 | DMSO : 5.56 mg/mL (7.31 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | XY028-140 is a selective CDK4/CDK6 degrader. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity in cancer cells[1]. A375 melanoma and T47D breast cancer cells are treated with 0.3 or 1 µμ XY028-140 for 24 hours. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity[1]. T47D breast cancer cells are treated with 0.03, 0.1, 0.3, 1, or 3 µμ XY028-140 for 11 days. XY028-140 inhibits cancer cell proliferation in breast cancer cells[1]. [1]. Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1. |
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