Afzelin (Kaempferol-3-O-rhamnoside) 是一种在鱼腥草 (Houttuynia cordata) 中发现的黄酮醇糖苷，广泛用于制备抗菌剂，解热剂，解毒剂和治疗炎症。 Afzelin 减弱线粒体损伤，增强线粒体生物合成，降低线粒体相关蛋白，帕金和 PTEN 诱导的假定激酶 1 (putative kinase 1) 的水平。Afzelin 可提高 D-半乳糖胺 (GalN)/LPS 处理的小鼠的存活率，降低丙氨酸氨基转移酶和促炎细胞因子的血清水平。
| Cas No. | 482-39-3 |
| 别名 | 阿福豆苷,Kaempferol-3-O-rhamnoside |
| Canonical SMILES | O=C1C(O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)=C(C3=CC=C(O)C=C3)OC4=CC(O)=CC(O)=C14 |
| 分子式 | C21H20O10 |
| 分子量 | 432.38 |
| 溶解度 | Ethanol: 50 mg/mL (115.64 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice[1]. [1]. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209. |
