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Bupranolol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bupranolol图片
CAS NO:14556-46-8
包装与价格：
包装价格(元)
5mg询价
25mg询价

Bupranolol 是一种口服活性、竞争性和非选择性 β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
Cas No.14556-46-8
别名布拉洛尔
分子式C14H22ClNO2
分子量271.78
溶解度DMSO : 50 mg/mL (183.97 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity[1].

Bupranolol (1~3 μM) shifts isoprenaline-induced relaxation in the presence of 30 μM propranolol. Bupranolol acts as a competitive antagonist of isoprenaline-induced relaxation in the presence of 300 nM propranolol, with a pA2 value of 5.90. Bupranolol antagonizes β1- and β2-ARs with pA2 values of ≈9.0, and also antagonizes β3-AR with a pA2 value of 6.0[1].

[1]. Chino D, et al. Pharmacological identification of β-adrenoceptor subtypes mediating isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle. J Smooth Muscle Res. 2018;54(0):13-27.
[2]. Babu RJ, et al. Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin. Int J Pharm. 2004;271(1-2):155-165.

 
 
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