| CAS NO: | 2040401-92-9 |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| Cas No. | 2040401-92-9 |
| 分子式 | C23H27N5O3S |
| 分子量 | 453.56 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1]. BI-6901 (intraperitoneal injection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1]. [1]. Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283. |
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