A 1070722 是一种有效的选择性糖原合酶激酶 3 (GSK-3) 抑制剂，对 GSK-3α 和 GSK-3β 的 Ki 均为 0.6 nM。 A 1070722 可以穿透血脑屏障 (BBB) 并在脑区积聚，因此有可能成为 PET 放射性示踪剂在脑中定量 GSK-3。
| Cas No. | 1384424-80-9 |
| 化学名 | (Z)-N'-(7-methoxyquinolin-4-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)carbamimidic acid |
| Canonical SMILES | COC1=CC2=NC=CC(/N=C(O)/NC3=CC=CC(C(F)(F)F)=N3)=C2C=C1 |
| 分子式 | C17H13F3N4O2 |
| 分子量 | 362.31 |
| 溶解度 | <36.23mg/ml in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain[1]. References:
[1]. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703. |
