N1-Acetylspermine(hydrochloride)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

77928-70-2

包装与价格：

包装	价格(元)
25mg	询价
50mg	询价

N1-Acetylspermine is a monoacetylated derivative of spermine, an endogenous polyamine synthesized from spermidine, that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.

Cas No.	77928-70-2
别名	N1-乙酰精胺三盐酸盐
化学名	N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-acetamide, trihydrochloride
Canonical SMILES	CC(NCCCNCCCCNCCCN)=O.Cl.Cl.Cl
分子式	C₁₂H₂₈N₄O•3HCl
分子量	353.8
溶解度	Water: 50 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	N1-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. [1] Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. [2][3] N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.[4] Reference: [1]. Bolkenius, F.N., and Seiler, N. Acetylderivatives as intermediates in polyamine catabolism. International Journal of Biochemistry 13(3), 287-292 (1981). [2]. Wallace, H.M., Fraser, A.V., and Hughes, A. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003). [3]. Igarashi, K., and Kashiwagi, K. Polyamines: Mysterious modulators of cellular functions. Biochemical and Biophysical Research Communications 271(3), 559-564 (2000). [4]. Aouida, M., Poulin, R., and Ramotar, D. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. The Journal of Biological Chemisty 285(9), 6275-6284 (2010).