| 化学名 | P-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl] ester-diphosphoric acid, triammonium salt |
| 产品描述 | Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug discovery.[3][4] Reference:
[1]. Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).
[2]. McTaggart, S.J. Isoprenylated proteins. Cell Mol.Life Sci. 63(3), 255-267 (2006).
[3]. Baron, R.A., and Seabra, M.C. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochemistry Journal 415(1), 67-75 (2008).
[4]. Maynor, M., Scott, S.A., Rickert, E.L., et al. Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs. Bioorganic & Medicinal Chemistry Letters 18(6), 1889-1892 (2008). |
