2,2,5,7,8-Pentamethyl-6-Chromanol

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CAS NO:

950-99-2

2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) 是维生素 E (α-tocopherol) 的抗氧化部分。2,2,5,7,8-Pentamethyl-6-Chromanol 具有有效的雄激素受体 (androgen receptor) 信号调节和抗前列腺癌细胞系的抗癌活性。

Cas No.	950-99-2
别名	3,4-二氢-2,2,5,7,8-五甲基-2H-1-苯并吡喃-6-酚,PMC
Canonical SMILES	OC1=C(C)C(C)=C2C(CCC(C)(C)O2)=C1C
分子式	C₁₄H₂₀O₂
分子量	220.31
溶解度	DMSO: 250 mg/mL (1134.76 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1]. [1]. Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.