Tauro-β-muricholic Acid(sodium salt)

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CAS NO:

145022-92-0

包装与价格：

包装	价格(元)
500μg	询价
1mg	询价
5mg	询价

Tauro-β-muricholic Acid sodium (T-βMCA sodium) 是一种内源性代谢物，是一种竞争性和可逆的法尼醇 X 受体 (FXR) 拮抗剂，IC50 为 40 μM.

Cas No.	145022-92-0
别名	牛磺-Α-鼠胆酸,Tauro-β-muricholate； TβMCA
化学名	2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
Canonical SMILES	C[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
分子式	C₂₆H₄₄NO₇S o Na
分子量	537.7
溶解度	1mg/ml in ethanol, 10mg/ml in DMSO & DMF
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
文献引用	Allergy (2021). PMID: 34365653
产品描述	Tauro-β-muricholic acid (TβMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 μM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid.[1] TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.[1],[2] TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.[3] Reference: 1. Sayin, S.I., Wahlstrom, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17(2), 225-235 (2013). 2. Wahlstrom, A., Kovatcheva-Datchary, P., Stahlman, M., et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J. Lipid. Res. 58(2), 412-419 (2017). 3. Qi, Y., Jiang, C., Cheng, J., et al. Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys. Acta. 1851(1), 19-29 (2015).