Nilutamide (Nilandron) 是一种口服活性的非甾体雄激素受体拮抗剂，对雄激素受体具有亲和力，但对孕激素、雌激素或糖皮质激素受体无亲和力。
| Cas No. | 63612-50-0 |
| 别名 | 尼鲁米特,Nilandron; RU 23908 |
| Canonical SMILES | O=C1N(C2=CC(C(F)(F)F)=C([N+]([O-])=O)C=C2)C(C(C)(C)N1)=O |
| 分子式 | C12H10F3N3O4 |
| 分子量 | 317.2 |
| 溶解度 | Chloroform: slightly soluble,DMSO: 25mM,Ethanol: 25mM,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor. It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro. It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg. Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer. |
