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Alloisolithocholic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Alloisolithocholic Acid图片
CAS NO:2276-93-9
包装与价格：
包装价格(元)
5mg询价
10mg询价
25mg询价

Alloisolithocholic Acid (3β-Hydroxy-5α-cholanic acid) 是 Lithocholic acid 的衍生物，是一种 T 细胞调节剂。
Cas No.2276-93-9
别名石胆酸杂质,AILCA
化学名(5α)-3β-hydroxy-cholan-24-oic acid
Canonical SMILESC[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式C24H40O3
分子量376.6
溶解度DMF: 1mg/mL,DMF:PBS (pH 7.2) (1:3): 0.25mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.[1],[2] It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 &#181M in Xenopus oocytes expressing human channels).[1] AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.[2]

Reference:
[1].Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008)
[2].Vonk, R.J., Tuchweber, B., MassE, D., et al.Intrahepatic cholestasis induced by allo monohydroxy bile acid in ratsGastroenterology80(2)242-249(1981)

 
 
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