CHD1Li 6.11 是一种有效的致癌 CHD1L 抑制剂 (对于 cat-CHD1L 重组蛋白，IC50=3.3 ?M)。CHD1Li 6.11 是一种口服生物可利用的抗肿瘤剂，显着减少由分离的准间充质细胞 (M 表型) 产生的 CRC 异种移植物的肿瘤体积，这些细胞具有增强的致瘤特性。
| Cas No. | 2716890-91-2 |
| 分子式 | C21H22BrN5OS |
| 分子量 | 472.4 |
| 溶解度 | DMSO : 100 mg/mL (211.69 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CHD1Li 6.11 is a potent oncogenic CHD1L inhibitor (IC50=3.3 µM for cat-CHD1L recombinant protein). CHD1Li 6.11 is an orally bioavailable antitumor agent, significantly reducing the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype), which possess enhanced tumorigenic properties[1]. [1]. Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022;65(5):3943-3961. |
