Chst15-IN-1 是一种有效的可逆共价 Chst15 抑制剂。Chst15-IN-1 有效抑制 chondroitin sulfate-E (CS-E) 硫酸盐化水平和其他密切相关的 glycosaminoglycans (GAG) sulfotransferases。Chst15-IN-1 作为一种选择性sulfotransferase 抑制剂可以降低 chondroitin sulfate proteoglycans (CSPGs) 的抑制作用，并有希望用于刺激神经元修复。
| Cas No. | 2158198-77-5 |
| 分子式 | C17H11BrCl2N2O3 |
| 分子量 | 442.09 |
| 溶解度 | DMSO : 50 mg/mL (113.10 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Chst15-IN-1 is a potent reversible covalentChst15inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely relatedglycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selectivesulfotransferaseinhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1]. Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression[1]. Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours[1]. | Animal Model: | Rats | | Dosage: | 3.0 mg/kg (Pharmacokinetic Analysis) | | Administration: | I.v. | | Result: | Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h. |
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