An internal standard for the quantification of cysteamine
| Cas No. | 1219805-04-5 |
| 别名 | 2-Aminoethanethiol-d4 hydrochloride; 2-Mercaptoethylamine-d4 hydrochloride |
| Canonical SMILES | NC([2H])([2H])C([2H])([2H])S.Cl |
| 分子式 | C2H3D4NS•HCl |
| 分子量 | 117.6 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cysteamine-d4is intended for use as an internal standard for the quantification of cysteamine (hydrochloride) by GC- or LC-MS. Cysteamine is a stable aminothiol with radioprotective activities.1It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner.1,2Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects.2In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts.3Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans. 1.Nelson, A.The protective effect of cysteamine on young mice exposed to roentgen raysActa. Radiol.42(6)485-493(1954)
2.Devik, F., and Lothe, F.The effect of cysteamine, cystamine and hypoxia on mortality and bone marrow chromosome aberrations in mice after total body roentgen irradiationActa. Radiol.44(3)243-248(1955)
3.Thoene, J.G., Oshima, R.G., Crawhall, J.C., et al.Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivoJ. Clin. Invest.58(1)180-189(1976) |
