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DC_C66
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DC_C66图片
CAS NO:108181-00-6

DC_C66 是一种细胞渗透性的，选择性的 (CARM1) 抑制剂，IC50 值为 1.8 μM。DC_C66 相对 PRMT1 (IC50=21 μM)，PRMT6 (IC50= 47μM)，PRMT5，具有良好的选择性。
Cas No.108181-00-6
Canonical SMILESO=C(OCC)C1=[N+]2C(C(C=CC=C3)=C3CC2)=CC4=C1C(C=CC=C5)=C5C6=C4C=CC=C6
分子式C28H22NO2+
分子量404.48
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1]. IC50: 1.8 μM (CARM1)[1]

DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: HELA, K562, MCF7 cells

[1]. Ye F, et al. Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. Biomed Res Int. 2016;2016:7086390.

 
 
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