| 包装: | 1mg |
| 市场价: | 3009元 |
| Canonical SMILES | OC(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](O)[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C)=O |
| 分子式 | C24H36D4O5 |
| 分子量 | 412.6 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | β-Muricholic acid-d4(β-MCA-d4) is intended for use as an internal standard for the quantification of β-muricholic acid by GC- or LC-MS. β-MCA is a murine-specific primary bile acid.1,2Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.3Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.4 1.Eyssen, H.J., Parmentier, G.G., and Mertens, J.A.Sulfate bile acids in germ-free and conventional miceEur. J. Biochem.66(3)507-514(1976) 2.WahlstrÖm, A., Sayin, S.I., Marschall, H.-I., et al.Intestinal crosstalk between bile acids and microbiota and its impact on host metabolismCell Metab.24(1)41-50(2016) 3.Fujino, Y., Nakayama, K., Yoshimura, K., et al.Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acidJpn. J. Pharmacol.46(4)421-423(1988) 4.Wang, D.Q.-H., and Tazuma, S.Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J miceJ. Lipid. Res.43(11)1960-1968(2002) |
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