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Indirubin Derivative E804
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Indirubin Derivative E804图片
CAS NO:854171-35-0

Indirubin Derivative E804, 是类胰岛素生长因子1型受体 (IGF1R) 的有效抑制剂，其 IC50 值为 0.65 μM。
Cas No.854171-35-0
Canonical SMILESO=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OCCC(O)CO
分子式C20H19N3O4
分子量365.38
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. IC50: 0.65 μM (IGF1R)[1].

Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1].

[1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962.

 
 
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