LOXO-292 (LOXO-292) 是一种有效的选择性 RET 激酶抑制剂，对 RET (WT)、RET (V804M) 和 RET (G810R) 的 IC50 值分别为 14.0 nM、24.1 nM 和 530.7 nM。 LOXO-292 具有抗癌活性。
| Cas No. | 2152628-33-4 |
| 别名 | 塞尔帕替尼; LOXO-292 |
| 化学名 | 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile |
| 分子式 | C29H31N7O3 |
| 分子量 | 525.613 |
| 溶解度 | DMF: 1 mg/ml,DMSO: 1 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | LOXO-292 (Selpercatinib, LOXO 292, LOXO292) is a potent, selective, orally availableRET kinaseinhibitor with potential antineoplastic activity; displays >100-fold selectivity versus important off-targets; shows anti-tumor activty in the brain and periphery in RET-dependent tumor models in vivo.Lung Cancer Reference：
[1]. Subbiah V, et al. Ann Oncol. 2018 Aug 1;29(8):1869-1876.
[2]. Cancer Discov. 2018 Aug;8(8):904-905. |
