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5'-Thymidylic Acid(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
5'-Thymidylic Acid(sodium salt)图片
CAS NO:33430-62-5
包装与价格：
包装价格(元)
100mg询价
250mg询价
1g询价

5'-胸苷酸（钠盐）是一种内源性代谢物。
Cas No.33430-62-5
别名胸苷酸二钠
Canonical SMILESO=C(N1)C(C)=CN([C@@]2([H])C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)C1=O.[Na+].[Na+]
分子式C10H13N2O8P•2Na
分子量366.2
溶解度PBS (pH 7.2): slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5'-Thymidylic acid (dTMP) is a deoxyribonucleotide.1It is formedviamethylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis.2Oral administration of dTMP in combination with dCMP increases lifespan in aTk2 H126Nknock-in mouse model of TK2 deficiency.3

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002) 2.Lee, L.S., and Cheng, Y.Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemiaJ. Biol. Chem.252(16)5686-5691(1977) 3.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)

 
 
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