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CL2-SN-38(dichloroacetic acid salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CL2-SN-38(dichloroacetic acid salt)图片
包装与价格：
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An antibody-drug conjugate containing SN-38
Canonical SMILESO=C([C@@]1(CC)OC(OCC2=CC=C(NC([C@H](CCCCN)NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN3C=C(CNC(C4CCC(CN5C(C=CC5=O)=O)CC4)=O)N=N3)=O)=O)CC6=CC=CC=C6)=O)=O)C=C2)=O)OCC7=C1C=C(C8=NC9=CC=C(O)C=C9C(CC)=C8C%10)N%10C7=O.OC(C(Cl)Cl)=O
分子式C82H106N12O23.XC2H2Cl2O2
分子量1627.8
溶解度DMSO: >1mg/mL,Ethanol: >1mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 and a maleimidocaproyl linker.1CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd= 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50= 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.

1.Moon, S., Govindan, S.V., Cardillo, T.M., et al.Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapyJ. Med. Chem.51(21)6916-6926(2008)

 
 
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