PIT 1 是一种选择性 PIP3（磷脂酰肌醇 3,4,5-三磷酸）拮抗剂。 PIT 1 通过抑制 PIP3 依赖性 PI3K/Akt 信号传导来抑制癌细胞存活并诱导细胞凋亡。 PIT 1 在体内表现出抗肿瘤活性。
| Cas No. | 53501-41-0 |
| 化学名 | N-((3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide |
| Canonical SMILES | ClC1=CC([N+]([O-])=O)=CC(NC(NC(C2=CC=CC=C2)=O)=S)=C1O |
| 分子式 | C14H10ClN3O4S |
| 分子量 | 351.76 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 0.5 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
