Enrofloxacin-d₅is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic.¹It is active against panels ofCampylobacter,E. coli, andSalmonellaisolates (mean MIC₅₀s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates ofL. intracellularis(MICs = 0.125-0.5 µg/ml).²Enrofloxacin inhibits bacterial DNA gyrase.³In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model of enteropathogenicE. coli-induced sepsis. Formulations containing enrofloxacin have been used in the treatment of veterinary bacterial infections.

1.Randall, L., Ridley, A., Lemma, F., et al.In vitro investigations into the use of antimicrobials in combination to maintain efficacy of fluoroquinolones in poultryRes. Vet. Sci.10847-53(2016) 2.Pereira, C.E.R., Resende, T.P., Vasquez, E., et al.In vitro antimicrobial activity against equine Lawsonia intracellularis strainsEquine Vet. J.51(5)665-668(2019) 3.Slate, A.R., Bandyopadhyay, S., Francis, K.P., et al.Efficacy of enrofloxacin in a mouse model of sepsisJ. Am. Assoc. Lab. Anim. Sci.53(4)381-386(2014)