NVS-PAK1-C 是一种有效的、ATP 竞争性和特异性变构 PAK1 抑制剂探针，对去磷酸化 PAK1 和磷酸化 PAK1 的 IC50 值分别为 5 nM 和 6 nM。 NVS-PAK1-C 还针对去磷酸化 PAK2 (IC50=270 nM) 和磷酸化 PAK2 (IC50=720 nM)。
| Canonical SMILES | FC(F)CN1C2=C(C=C(Cl)C=C2)C(N[C@H]3CCN(C(N(C)C)=O)C3)=NC4=C1C=CC(F)=C4 |
| 分子式 | C22H23ClF3N5O |
| 分子量 | 465.9 |
| 溶解度 | DMF: 50 mg/ml,DMSO: 50 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 20 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NVS-PAK1-C is a negative control for the allosteric PAK1 inhibitor NVS-PAK1-1 . See the Structural Genomic Consortium (SGC) website for more information. |
