LMD-009是选择性CCR8非肽激动剂。LMD-009以高效力介导趋化性，肌醇磷酸盐积累和钙释放，EC50为11至87nM。
| Cas No. | 950195-51-4 |
| Canonical SMILES | O=C1NCN(CCC2=CC=CC=C2)C13CCN(CC4=CC=CC(OC5=CC=CC=C5OC)=C4)CC3 |
| 分子式 | C29H33N3O3 |
| 分子量 | 471.59 |
| 溶解度 | DMSO: 250 mg/mL (530.12 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM[1]. [1]. Jensen PC, et al. Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. Mol Pharmacol. 2007 Aug;72(2):327-40. |
